The Buffalo Bills hammered the San Francisco 49ers 35-10 in a snow-filled rout led by Josh Allen’s 4 TDs. Colin Cowherd ...

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...

The Bills are a Super Bowl contender and the 49ers somehow probably aren’t even a playoff team. That’s how Sunday night’s ...

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San ...

The 49ers look to turn around their season with a win in Buffalo against the Bills, who are chasing the top seed in the AFC.

Including the playoff game, Shanahan’s 49ers have beaten McVay’s Rams in 10 of 16 games. The two worked together for a year ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

Josh Allen and Buffalo are quickly emerging as Super Bowl favorites after delivering another stellar performance on Sunday ...

The San Francisco 49ers right now have +15000 odds of winning the Super Bowl. The 49ers were knocked off by the Buffalo Bills 35-10 in their most recent game. Brock Purdy had 94 yards on 11-of-18 ...

The San Francisco 49ers face a pivotal offseason as their once-promising season spirals further from playoff contention.

Matt Maiocco sifts through 49ers fan reactions -- and overreactions- after San Francisco's blowout loss to the Buffalo Bills.