San Francisco fumbled the ball three times and lost all three. Brock Purdy dropped back to pass 20 times for 86 net yards. Only one 49er had more than 20 receiving yards and the team’s lone touchdown came late in the third quarter after the Bills had already built a 28-3 lead.

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark Field.

One week after an incredible finish in the snow in Cleveland, there's likely another whiteout game on hand for NFL fans. Here's what to know about the weather for the Bills vs. 49ers game in Buffalo on Sunday night. Snow fell steadily on Saturday and ...