The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...

Lake-effect snow has been hitting Buffalo throughout the holiday weekend with is expected to continue off and on through ...

Bills on NBC's Sunday Night Football, the NFL Week 13 schedule and more. More: NFL playoff picture: Chiefs become ...

Finally, it's over. The San Francisco 49ers suffered an abysmal 35-10 loss to the Buffalo Bills. It wasn't a close game at all for the 49ers. Buffalo was in con ...

The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFC West. Here are their grades for this per ...

For the first time in nearly 14 months, the Bills had star linebacker Matt Milano available to them in an actual game. After ...

After games on both Thanksgiving and Black Friday, the NFL caps off the Sunday slate with the Buffalo Bills hosting the San ...

Josh Allen became the first quarterback since 1970 to score a rushing touchdown, pass for a touchdown and have a scoring ...

Amari Cooper explained his decision to lateral to Josh Allen during the Bills' surreal touchdown vs. the 49ers.

After U.S. travelers battled through harsh weekend weather to reach home following the Thanksgiving holiday, forecasters say ...

The Buffalo Bills beat the San Francisco 49ers to clinch their fifth-straight AFC East Championship, but what could be more ...