George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...

San Francisco played without four key players - quarterback Brock Purdy, left tackle Trent Williams, defensive end Nick Bosa ...

Here’s how you can watch, stream and listen to the game. Bills vs. 49ers will air on NBC. Mike Tirico will be on play-by-play ...

This Sean McDermott stat should give Buffalo Bills fans confidence entering their Week 13 matchup with the San Francisco ...

The San Francisco 49ers and Buffalo Bills will clash on "Sunday Night Football." Here's how to watch the Week 13 NFL game ...

The San Francisco 49ers are playing Brandon Allen at quarterback in Week 12 against the Green Bay Packers. The team’s ...

The San Francisco 49ers are optimistic about the status of quarterback Brock Purdy for their Week 13 clash with the Buffalo ...

The Bills return from their bye week with a tough test on Sunday Night Football. Here's a look ahead to the matchup.

Next up for Bills, 9-2, are the beleaguered San Francisco 49ers, 5-6, who limp into Highmark Stadium on Sunday night riding a ...

San Francisco has put up a combined 27 points the past two weeks and faces a Bills defense great at generating pressure with ...

The San Francisco 49ers will hold three full practices this week as they prepare for their Week 13 matchup against the ...