San Francisco 49ers running back Christian McCaffrey (knee) suffered a PCL injury just four games into his return from the ...

It’s been an arduous year for Christian McCaffrey. A lingering Achilles injury cost him the first nine weeks of the season. Now, after just four games, he’s back on the shelf. What injury is McCaffrey ...

San Francisco 49ers head coach Kyle Shanahan addressed reporters during a Monday conference call, a day after the team's dominant 38-13 victory over the Chicago Bears. He shared several injury updates ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

The San Francisco 49ers have been dealing with all sorts of injury concerns in their offensive backfield. Star running back ...

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and is questionable to return in Sunday's ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve and is likely out for the season after suffering a PCL injury in Week 13 agai ...

San Francisco 49ers head coach Kyle Shanahan and quarterback Brock Purdy spoke with reporters after Friday's practice as the ...

Superstar edge rusher Nick Bosa is officially ruled out for Sunday's contest against the Bears, according to ESPN's Adam ...

RB Christian McCaffrey looked to finally be taking off after his return from an Achilles injury but suffered a PCL injury ...

San Fransisco 49ers running back Christian McCaffrey already missed the first eight games of the NFL season due to ...

The San Francisco 49ers are in the midst of a down season. At 5-7, the 49ers will likely miss the postseason, spurning rumors ...