The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

The 49ers were among the preseason favorites to win the Super Bowl, but now they look like long shots to make the playoffs.

In a disappointing season a team typically reaches a point of no return, a realization that, “we have met the enemy, and it ...

The 49ers season is still trending down and now they're searching for answers on if they can get back on track.

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...

After Sunday night's humbling loss in snowy Buffalo, it's time for Kyle Shanahan and John Lynch to start shutting ...

The San Francisco 49ers received some brutal news on Sunday evening. According to head coach Kyle Shanahan, running back ...

The San Francisco 49ers' losses to the Green Bay Packers and Buffalo Bills mark the worst two-game stretch by a defending ...

San Francisco 49ers running back Christian McCaffrey could be done for the season after just four games. As head coach Kyle ...

Buffalo was a perfect 4-for-4 in the red zone. A big factor in the Bills' success was their run game. RB James Cook had 14 ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

The San Francisco 49ers are bracing for the worst-case scenario on Christian McCaffrey's latest injury. On Sunday, McCaffrey went down with a non-contact ...