After sparking the 49ers with a handful of impressive runs, Christian McCaffrey looked like himself early in the game against ...

The Week 13 Sunday slate closes with the Buffalo Bills (9-2) hosting the San Francisco 49ers (5-6) on Sunday Night Football.

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

McCaffrey immediately checked himself out of the game and ran right into the medical tent. The 49ers star RB missed the ...

Buffalo Bills quarterback Josh Allen had fun in the snow as his team produced an offensive avalanche to blow away the San ...

Former Wisconsin running back Isaac Guerendo scored the second touchdown of his young NFL career in the San Francisco 49ers’ ...

The San Francisco 49ers entered Sunday night's matchup against the Buffalo Bills at Highmark Stadium without several key ...

The Pittsburgh Steelers outlasted the Cincinnati Bengals in a 44-38 win on the road. Quarterback Russell Wilson had a vintage ...

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Josh Allen scored one of the more remarkable touchdowns of this — or any — season Sunday night in Buffalo's 35-10 blowout of ...

The San Francisco 49ers running back has sustained a posterior cruciate ligament (PCL) injury, head coach Kyle Shanahan ...

Christian McCaffrey has barely played this season. But the star running back could already be done for the year. On a snowy ...