Back-to-back blowout losses and another injury to star back Christian McCaffrey might just be the final blow to the dwindling ...

It’s been a rough day – and a rough season - for 49ers fans. Many are depressed over a brutal loss Monday night in Buffalo ...

Running back Christian McCaffrey will go on injured reserve with a posterior cruciate ligament strain that may not need ...

The dark and gloomy 2024 season gets worse for the San Francisco 49ers. On Monday, Kyle Shanahan delivered the worst-case ...

Kyle Shanahan's team is now on a three-game losing streak, two games out of first place with only five games left to play, ...

The 49ers received more bad news on the injury front on Monday. Who starts at running back with McCaffrey and Mason out?

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

The 24-year-old Guerendo was a fourth-round pick in the 2024 NFL draft. He transferred to Louisville for the 2023 season ...

Replacing McCaffrey won't be easy for fantasy football managers, but these three running backs present the most viable ...

It's Buffalo Bills vs San Francisco 49ers in Week 13 of the NFL season. Can Josh Allen and company outduel Christian McCaffery and Deebo Samuel?

McCaffrey suffered a potentially season-ending PCL injury, 49ers coach Kyle Shanahan said after the 35-10 loss to the Bills.