San Francisco 49ers’ Christian McCaffrey is one of the most exciting talents in NFL. While his professional accomplishments ...

After sparking the 49ers with a handful of impressive runs, Christian McCaffrey looked like himself early in the game against ...

McCaffrey immediately checked himself out of the game and ran right into the medical tent. The 49ers star RB missed the ...

Fantasy football analyst Matt Harmon delivers his thoughts on the major happenings of Week 13's Sunday action.

San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second ...

The San Francisco 49ers suffered another embarrassing defeat on Sunday night, this time coming at the hands of the Buffalo ...

San Francisco 49ers star running back Christian McCaffrey departed Sunday night's snow game against the Buffalo Bills early ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...

Christian McCaffrey pulled up limping after taking a pitch early in their game against the Bills on Sunday night.