The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

Christian McCaffrey pulled up limping after taking a pitch early in their game against the Bills on Sunday night.

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...

You may have caught a glimpse of Buffalo Bills offensive lineman Alec Anderson during the celebration of James Cook’s 65-yard touchdown that opened the floodgates of scoring against the San Francisco ...

The San Francisco 49ers will face tough weather in their "Sunday Night Football" matchup against the Buffalo Bills as snow ...

Watch highlights from the Week 13 matchup between the San Francisco 49ers and the Buffalo Bills during the 2024 ...

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San ...

Officials in upstate New York counties have declared a state of emergency as they prepare for a major snowstorm that has ...

The Buffalo Bills dominated the San Francisco 49ers on Sunday night, winning 35-10 in Highmark Stadium in Orchard Park, N.Y.

The 49ers had three fumbles in Sunday night's contest, all three of which were recovered by the Bills. San Francisco's ...

The 49ers were absolutely shellacked Sunday for a second straight week as the Buffalo Bills beat them 35-10 on national ...

Christian McCaffrey will not return to Sunday's matchup against the Bills. McCaffrey has been downgraded to out with the knee ...