The San Francisco 49ers received some brutal news on Sunday evening. According to head coach Kyle Shanahan, running back Christian McCaffrey suffered a potentially season-ending PCL injury in their 35–10 loss against the Buffalo Bills.

San Francisco 49ers running back Christian McCaffrey could be done for the season after just four games. As head coach Kyle Shanahan relayed after the

Dre Greenlaw practiced for the first time this week since he tore his Achilles in the Super Bowl. Here's what head coach Kyle Shanahan said about Greenlaw's wee

San Francisco head coach Kyle Shanahan discussed what it will take for the 49ers to ignite receiver Deebo Samuel’s production.

The 49ers are struggling at 5-6. They have a tough game in Buffalo on Sunday night. A loss would further complicate their path to the postseason. So how is the current vibe in the locker room?

Purdy missed the 49ers' Week 12 contest versus the Green Bay Packers last Sunday with a right shoulder injury—a game San Francisco lost 38–10. The 25-year-old was limited in practice this week on Wednesday and Thursday, and was a full participant on Friday. He's officially listed as questionable for Sunday.

The NFL is reviewing the sideline scuffle between San Francisco 49ers linebacker Dre Greenlaw and Philadelphia Eagles' head of security, Dom DiSandro. Both individuals were ejected from Sunday's game.